Research Only Healing & Recovery

KPV

also known as: Lys-Pro-Val, α-MSH(11-13), tripeptide KPV

A tripeptide derived from α-MSH with potent anti-inflammatory activity — studied in preclinical models of IBD, psoriasis, and acne.

The terminal three residues (lysine-proline-valine) of alpha-melanocyte-stimulating hormone, retaining anti-inflammatory activity while avoiding the pigmentary effects of the full α-MSH peptide.

Mechanism of action

Acts inside cells rather than through α-MSH receptors — binds intracellular targets and inactivates inflammatory signaling cascades including NF-κB, reducing cytokine release (TNF-α, IL-1β, IL-6) and leukocyte migration. Unlike full α-MSH, KPV lacks the N-terminal residues required for melanocortin receptor activation, so produces anti-inflammatory effects without pigmentation change.

Primary uses

Inflammatory bowel disease research
Psoriasis and acne research
Candidate for gut barrier inflammation
Community oral use for gut healing (combined with BPC-157)

Typical dosing

200–500 mcg once daily (oral (community); preclinical via various routes)

Community oral dosing; no clinical standard.

Regulatory status

Not approved. Preclinical research peptide. Studied in colitis and skin inflammation models.

References

[pubmed] Dalmasso G, et al. "PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation." Gastroenterology, 2008;134:166-178.
[pubmed] Kannengiesser K, et al. "Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease." Inflamm Bowel Dis, 2008;14:324-331.

Related peptides

BPC-157

A synthetic pentadecapeptide from gastric protein, widely studied in animal models for tendon, ligament, and gastrointestinal healing.

Larazotide

A zonulin antagonist — the most clinically advanced "leaky gut" candidate, with positive Phase 2b data in celiac disease but a failed Phase 3 trial readout in 2022.

LL-37

The only human cathelicidin — an antimicrobial peptide with direct activity against bacteria, fungi, viruses, and biofilms, with additional roles in wound healing and immune signaling.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.