Research Only Cosmetic & Skin

AHK-Cu

also known as: AHK copper peptide, Ala-His-Lys-copper

A tripeptide copper complex studied primarily for hair follicle stimulation and anagen induction in cosmetic applications.

A tripeptide (Ala-His-Lys) chelated with copper(II), structurally related to GHK-Cu but with research interest concentrated on hair follicle biology rather than skin remodeling.

Mechanism of action

Copper-peptide complex that increases VEGF expression in dermal papilla cells and prolongs the anagen (growth) phase of the hair cycle in preclinical models. Copper itself is a cofactor for lysyl oxidase and several antioxidant enzymes; the tripeptide carrier is proposed to improve cellular delivery.

Primary uses

  • Hair growth and anti-alopecia (cosmetic research)
  • Scalp formulations
  • Wound healing (limited)

Typical dosing

topical 0.1–0.5% once or twice daily (topical)

Typical cosmetic formulation range. No systemic dosing established.

Regulatory status

Not approved as a drug. Used as a cosmetic ingredient in hair serums and scalp formulations. Most evidence is in vitro and animal-model.

References

  1. [pubmed] Pyo HK, et al. "The effect of tripeptide-copper complex on human hair growth in vitro." Arch Pharm Res, 2007;30:834-839.
  2. [review] Pickart L, Margolina A. "Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data." Int J Mol Sci, 2018;19:1987.

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Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.