Category · 21 entries
Cosmetic & Skin
Peptides studied for skin, hair, and cosmetic applications.
Acetyl Hexapeptide-30
Inyline — Lipotec's post-synaptic cosmetic peptide. Unlike Argireline-family pre-synaptic SNAP-25 mimetics or Vialox-style nAChR antagonists, Acetyl Hexapeptide-30 is claimed to block the agrin-MuSK interaction that maintains post-synaptic AChR clustering; was formerly INCI Acetyl Hexapeptide-25.
Acetyl Hexapeptide-37
The Lipotec "Diffuporine" cosmetic peptide — identified by luciferase-reporter combinatorial screening as an AQP3 inducer; increases epidermal water transport and barrier proteins at cosmetic concentrations; entirely topical, no systemic development.
Acetyl Octapeptide-3
The 'Super Argireline' — an extended SNAP-25 fragment peptide that reduces expression wrinkles without injections.
Acetyl Tetrapeptide-2
Uplevity — a Lipotec firming tetrapeptide proposed to support dermal mechanotransduction by organising elastin, fibulin-5, and LOXL-family enzymes. Follow-on "skin architect" peptide marketed as alternative to pre-synaptic/post-synaptic muscle peptides; manufacturer-only efficacy data.
Acetyl Tetrapeptide-5
Eyeseryl — the anti-puffiness eye peptide. A β-alanine-containing acetyl-tetrapeptide claimed to reduce capillary permeability and inhibit glycation-driven cross-linking; low absolute concentrations (0.01 % active) but convincing before/after in manufacturer studies.
AHK-Cu
A tripeptide copper complex studied primarily for hair follicle stimulation and anagen induction in cosmetic applications.
Argireline
A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.
Biotinoyl Tripeptide-1
A biotin-peptide hybrid for hair loss — combining GHK's tissue repair signaling with biotin to strengthen follicles and reduce thinning.
Botulinum Toxin
A bacterial toxin that cleaves SNAP-25 to silence nerve endings: approved for migraine, bladder, spasticity and more, under a boxed warning.
Collagen Peptides
Hydrolysed collagen taken by mouth, a mixture of short peptides rather than one molecule. Randomised trials at 2.5 to 15 g a day report better skin elasticity and hydration, higher bone mineral density in postmenopausal women, less activity-related knee pain. A dietary supplement, not an approved medicine.
Hyaluronic Acid
A sugar chain, not a peptide: FDA-approved as fillers and joint injections, brand by brand, with thinner evidence as a supplement.
Leuphasyl
A cosmetic-ingredient pentapeptide modeled on leucine-enkephalin — marketed by Lipotec as a post-synaptic adjunct to Argireline-class pre-synaptic peptides for expression-line reduction.
Pal-GHK
The palmitoylated form of the GHK tripeptide (distinct from GHK-Cu) — widely used as a cosmetic ingredient in combination with Matrixyl (Matrixyl 3000 is Pal-GHK + Pal-KTTKS) for fine-line reduction.
Palmitoyl Hexapeptide-12
Biopeptide EL — a palmitoyl-VGVAPG elastin "spring fragment" peptide. The VGVAPG sequence is chemotactic for fibroblasts and binds the elastin receptor complex (GLB1 / cathepsin-A / NEU-1); cosmetic firmness claims rest mostly on manufacturer data.
Palmitoyl Pentapeptide-4
The palmitoylated procollagen fragment sold as Matrixyl (pal-KTTKS): in a 12-week split-face trial in 93 women a moisturiser containing it reduced wrinkles more than the same moisturiser alone. A cosmetic ingredient, not a drug.
Palmitoyl Tetrapeptide-7
The anti-inflammatory partner in Matrixyl 3000 — a lipopeptide that reduces IL-6 and glycation damage in aging skin.
Palmitoyl Tripeptide-38
Sederma's Matrixyl Synthe'6 — a palmitoyl tripeptide (Pal-KMO2K) claimed to stimulate six dermal-matrix components (collagens I / III / IV, fibronectin, hyaluronic acid, laminin-5). Follow-on to Matrixyl and Matrixyl 3000; almost all efficacy data is manufacturer-generated.
Palmitoyl Tripeptide-5
Syn-Coll / Pal-KVK — a palmitoyl tripeptide modeled on the thrombospondin-1 motif that activates latent TGF-β. Mechanistically distinct from Matrixyl-family matrikines: activates a growth-factor signalling pathway rather than directly mimicking collagen fragments. Cosmetic ingredient only.
Pentapeptide-3
Vialox — the "curare-mimetic" cosmetic peptide (GPRPA). Acts post-synaptically on peripheral nicotinic ACh receptors, unlike the pre-synaptic SNAP-25-mimetic Argireline class. Sometimes marketed as a snake-venom-inspired Botox alternative; efficacy data are primarily from the manufacturer.
Syn-Ake
A "snake-venom mimetic" cosmetic tripeptide modeled on Waglerin-1 (Tropidolaemus wagleri venom) — blocks post-synaptic acetylcholine receptors rather than acting pre-synaptically like Argireline; modest reductions in expression-line depth in manufacturer studies.
Tripeptide-10 Citrulline
The INCI name for the active peptide in Decorinyl® — a tetrapeptide (KDI-Cit) whose charge pattern (+/−/0/+) reproduces decorin's collagen-binding motif. Decorinyl is the trade name of this molecule; both names lead to this entry.