supplement Cosmetic & Skin

Biotinoyl Tripeptide-1

also known as: Biotinyl-GHK, Procapil component

A biotin-peptide hybrid for hair loss — combining GHK's tissue repair signaling with biotin to strengthen follicles and reduce thinning.

A conjugate of biotin (vitamin B7) with the tripeptide GHK that strengthens hair follicle anchoring, reduces DHT-mediated miniaturization, and improves hair matrix cell metabolism — the peptide component of the popular hair loss formulation Procapil.

Mechanism of action

The GHK motif stimulates extracellular matrix production in the dermal papilla. Biotin conjugation enhances metabolic activity of hair matrix keratinocytes. In Procapil, works synergistically with oleanolic acid (5-alpha-reductase inhibitor) and apigenin (vasodilator).

Primary uses

Anti-hair-loss scalp treatments (as Procapil)
Strengthening follicle anchoring
Hair growth serums and shampoos

Typical dosing

1-3 % Procapil in formulation once daily (topical (scalp))

Results typically visible after 3-6 months.

Regulatory status

Cosmetic/hair care ingredient. Key component of Procapil (Biotinoyl Tripeptide-1 + Oleanolic acid + Apigenin) by Sederma/Croda.

References

[review] Kapoor R, et al. "Peptides in dermatology: a review." Indian Dermatol Online J. 2020;11(5):721-728.

Related peptides

GHK-Cu

A naturally occurring human tripeptide-copper complex with extensive topical cosmetic evidence and strong in-vitro data on collagen synthesis, angiogenesis, and anti-inflammatory signaling.

Pal-GHK

The palmitoylated form of the GHK tripeptide (distinct from GHK-Cu) — widely used as a cosmetic ingredient in combination with Matrixyl (Matrixyl 3000 is Pal-GHK + Pal-KTTKS) for fine-line reduction.

Palmitoyl Pentapeptide-4

The collagen-boosting cosmetic peptide — a palmitoylated 5-amino-acid fragment that signals fibroblasts to produce more collagen, documented in double-blind studies to reduce wrinkle depth.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.