Part of the skin and hair peptide hub: every topical and cosmetic peptide we cover, with its evidence grade.

Evidence: LowPeptide supplement Cosmetic & Skin

Biotinoyl Tripeptide-1

also known as: Biotinyl-GHK, Procapil component

A biotin-peptide hybrid for hair loss — combining GHK's tissue repair signaling with biotin to strengthen follicles and reduce thinning.

A conjugate of biotin (vitamin B7) with the tripeptide GHK that strengthens hair follicle anchoring, reduces DHT-mediated miniaturization, and improves hair matrix cell metabolism — the peptide component of the popular hair loss formulation Procapil.

Mechanism of action

The GHK motif stimulates extracellular matrix production in the dermal papilla. Biotin conjugation enhances metabolic activity of hair matrix keratinocytes. In Procapil, works synergistically with oleanolic acid (5-alpha-reductase inhibitor) and apigenin (vasodilator).

Primary uses

Anti-hair-loss scalp treatments (as Procapil)
Strengthening follicle anchoring
Hair growth serums and shampoos

Typical dosing

No sourced amount

The concentrations in circulation come from the ingredient's supplier, and a seller's figure is not a source on this site; no study in the sources read sets one.

Regulatory status

Cosmetic/hair care ingredient. Key component of Procapil (Biotinoyl Tripeptide-1 + Oleanolic acid + Apigenin) by Sederma/Croda.

Status as of this entry's last review, April 21, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.

What the studies show

Biotinoyl tripeptide-1 is biotin joined to the copper-binding tripeptide GHK, sold as part of the hair-care blend Procapil. No study has tested the peptide alone; the two trials below tested Procapil alongside platelet-rich plasma (PRP), and they point in different directions.

Human · 2024

Procapil added to PRP

In a non-randomised trial in 160 people with androgenetic alopecia, those given PRP plus topical 5% Procapil twice daily scored better at six months on dermatologist ratings and patient satisfaction than those given PRP alone.

PMID 39609969

Human · 2023

Procapil against another topical blend

In a randomised trial in 54 men with androgenetic alopecia, PRP with Procapil was compared with PRP plus Redensyl, saw palmetto and biotin; grading differed significantly between groups, and the authors concluded the Redensyl combination was the better option.

PMID 37292551

References

[review] Kapoor R, et al. "Peptides in dermatology: a review." Indian Dermatol Online J. 2020;11(5):721-728.
[pubmed] Khoso H, et al. "COMPARISON OF PLATELET RICH THERAPY ALONE WITH PLATELET RICH THERAPY ALONG WITH DAILY TOPICAL 5% PROCAPIL APPLICATION FOR THE TREATMENT OF ANDROGENETIC ALOPECIA." J Ayub Med Coll Abbottabad, 2024;36(2):299-304. PMID: 39609969.
[pubmed] Tr P, et al. "A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia." Cureus, 2023;15(5):e38696. PMID: 37292551.

Related peptides

GHK-Cu

A copper-binding tripeptide found in human plasma and sold widely in skin care; the evidence is mostly cell and animal work, with few trials in people.

Pal-GHK

The palmitoylated form of the GHK tripeptide (distinct from GHK-Cu) — widely used as a cosmetic ingredient in combination with Matrixyl (Matrixyl 3000 is Pal-GHK + Pal-KTTKS) for fine-line reduction.

Palmitoyl Pentapeptide-4

The palmitoylated procollagen fragment sold as Matrixyl (pal-KTTKS): in a 12-week split-face trial in 93 women a moisturiser containing it reduced wrinkles more than the same moisturiser alone. A cosmetic ingredient, not a drug.

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Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.