Acetyl SH-Heptapeptide-1
Ac-DEETGEF, an acidic cosmetic heptapeptide. PubMed holds no study of it under its INCI name.
Acetyl sh-heptapeptide-1 is a synthetic heptapeptide, Ac-Asp-Glu-Glu-Thr-Gly-Glu-Phe (PubChem lists it under its INCI name, with the synonym acetyl heptapeptide-20, and links a ChEMBL record). It is sold as a skin-care ingredient, but a title-and-abstract search of PubMed for either name finds no study of it. It is not a drug.
No dosing data yet Details ↓
Recommended Dosing
No dosing data yet
This page has no dosing data yet.
Mechanism of action
Not established: no published study describes its action.
Primary uses
- Cosmetic skin-care formulations
Typical dosing
No published study states an amount of this ingredient used on skin, and a supplier's use level is not a source on this site, so none is given.
Regulatory status
Not a drug: PubChem lists it under its INCI name as a cosmetic ingredient (CID 122190547). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).
Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.
What we checked
Acetyl SH-Heptapeptide-1 is a cosmetic peptide ingredient with little or no published literature; this section records what can be checked.
Identity, computed
| Sequence | Ac-Asp-Glu-Glu-Thr-Gly-Glu-Phe (Ac-DEETGEF) |
| Formula | C36H49N7O18 |
| Average mass | 867.82 g/mol |
| Monoisotopic mass | 867.3134 Da |
| Isoelectric point | 0.0 (net charge -5.0 at pH 7) |
The sequence is the one PubChem's record gives for the INCI ingredient; the values below are computed and agree with PubChem's formula.
Regulatory status, read October 28, 2026
Drugs@FDA: 0 records for “acetyl sh-heptapeptide-1”. EMA medicines list: 0 records for “acetyl sh-heptapeptide-1”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 80 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.
What we looked for and did not find
No published study of any kind, no registry record and no drug approval.
| Source | Query | Results, October 28, 2026 | What it was |
|---|---|---|---|
| PubMed | ("sh-heptapeptide-1"[tiab] AND acetyl[tiab]) OR ("heptapeptide-20"[tiab] AND acetyl[tiab]) | 0 | names matched word by word |
| ClinicalTrials.gov | acetyl sh-heptapeptide-1 | 0 | |
| Drugs@FDA (openFDA) | acetyl sh-heptapeptide-1 | 0 | |
| EMA medicines list | acetyl sh-heptapeptide-1 | 0 |
References
- [other] PubChem CID 122190547, Acetyl SH-Heptapeptide-1: formula C36H49N7O18, molecular weight 867.8. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/122190547
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This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.