Research Only Cosmetic & Skin

Leuphasyl

also known as: Pentapeptide-18, Tyr-D-Ala-Gly-Phe-Leu

A cosmetic-ingredient pentapeptide modeled on leucine-enkephalin — marketed by Lipotec as a post-synaptic adjunct to Argireline-class pre-synaptic peptides for expression-line reduction.

A synthetic enkephalin analog (Tyr-D-Ala-Gly-Phe-Leu) developed by Lipotec as a cosmetic ingredient, proposed to reduce acetylcholine release at the neuromuscular junction through a δ-opioid receptor-mediated pathway on motor neurons.

Mechanism of action

Proposed to act at δ-opioid receptors on motor neuron terminals to reduce acetylcholine release. Manufacturer claims are that the mechanism is complementary to Argireline's SNAP-25 competitive inhibition, and that the combination produces additive expression-line reduction.

Primary uses

Topical cosmetic anti-aging formulations (expression-line reduction)

Typical dosing

2–5 % (topical formulation) daily topical application (topical)

Often co-formulated with Argireline.

Regulatory status

Cosmetic ingredient; not a drug.

References

[manufacturer] Lipotec. "Leuphasyl technical data sheet and cosmetic ingredient profile."

Related peptides

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Syn-Ake

A "snake-venom mimetic" cosmetic tripeptide modeled on Waglerin-1 (Tropidolaemus wagleri venom) — blocks post-synaptic acetylcholine receptors rather than acting pre-synaptically like Argireline; modest reductions in expression-line depth in manufacturer studies.

SNAP-8

An octapeptide cosmetic ingredient extending the Argireline concept — same SNAP-25 competitive mechanism with two additional residues and claims of enhanced activity.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.