Research Only Cosmetic & Skin

Leuphasyl

also known as: Pentapeptide-18, Tyr-D-Ala-Gly-Phe-Leu

A cosmetic-ingredient pentapeptide modeled on leucine-enkephalin — marketed by Lipotec as a post-synaptic adjunct to Argireline-class pre-synaptic peptides for expression-line reduction.

A synthetic enkephalin analog (Tyr-D-Ala-Gly-Phe-Leu) developed by Lipotec as a cosmetic ingredient, proposed to reduce acetylcholine release at the neuromuscular junction through a δ-opioid receptor-mediated pathway on motor neurons.

Mechanism of action

Proposed to act at δ-opioid receptors on motor neuron terminals to reduce acetylcholine release. Manufacturer claims are that the mechanism is complementary to Argireline's SNAP-25 competitive inhibition, and that the combination produces additive expression-line reduction.

Primary uses

Topical cosmetic anti-aging formulations (expression-line reduction)

Typical dosing

2–5 % (topical formulation) daily topical application (topical)

Often co-formulated with Argireline.

Regulatory status

Cosmetic ingredient; not a drug.

References

[manufacturer] Lipotec. "Leuphasyl technical data sheet and cosmetic ingredient profile."

Related peptides

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Syn-Ake

A "snake-venom mimetic" cosmetic tripeptide modeled on Waglerin-1 (Tropidolaemus wagleri venom) — blocks post-synaptic acetylcholine receptors rather than acting pre-synaptically like Argireline; modest reductions in expression-line depth in manufacturer studies.

SNAP-8

An octapeptide cosmetic ingredient extending the Argireline concept — same SNAP-25 competitive mechanism with two additional residues and claims of enhanced activity.

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Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.