Research Only Cosmetic & Skin

SNAP-8

also known as: Acetyl Octapeptide-3, Acetyl glutamyl heptapeptide-1

An octapeptide cosmetic ingredient extending the Argireline concept — same SNAP-25 competitive mechanism with two additional residues and claims of enhanced activity.

An elongated version of Argireline (acetyl octapeptide-3) marketed by Lipotec as a second-generation SNAP-25 mimic for topical expression-line reduction.

Mechanism of action

Same mechanism as Argireline — competes with SNAP-25 at the SNARE complex, reducing acetylcholine release at the neuromuscular junction. Manufacturer studies claim enhanced potency vs Argireline at equivalent concentrations, but independent replication is limited.

Primary uses

Topical anti-aging cosmetic formulations

Typical dosing

5–10 % (topical formulation) daily topical application (topical)

Cosmetic concentrations.

Regulatory status

Cosmetic ingredient; not a drug.

References

[manufacturer] Lipotec. "SNAP-8 technical data sheet and cosmetic ingredient profile."

Related peptides

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Matrixyl

A palmitoylated pentapeptide derived from a collagen-I breakdown fragment (KTTKS) — widely used in cosmetic topicals with clinical data supporting modest reductions in fine-line depth over 12 weeks.

GHK-Cu

A naturally occurring human tripeptide-copper complex with extensive topical cosmetic evidence and strong in-vitro data on collagen synthesis, angiogenesis, and anti-inflammatory signaling.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.