Research Only Cosmetic & Skin

Matrixyl

also known as: Palmitoyl Pentapeptide-4, Palmitoyl Pentapeptide-3, Pal-KTTKS, Matrixyl 3000

A palmitoylated pentapeptide derived from a collagen-I breakdown fragment (KTTKS) — widely used in cosmetic topicals with clinical data supporting modest reductions in fine-line depth over 12 weeks.

A lipopeptide formed by conjugation of palmitic acid to the collagen-I-derived matrikine KTTKS (Lys-Thr-Thr-Lys-Ser), developed by Sederma and used in cosmetic formulations to stimulate fibroblast collagen synthesis via mimicry of the natural collagen degradation feedback loop.

Mechanism of action

The KTTKS fragment is a natural signal produced by collagen-I degradation; fibroblasts respond to KTTKS as a feedback signal by upregulating collagen and glycosaminoglycan synthesis. Palmitoylation enables skin penetration of the otherwise hydrophilic peptide. Clinical studies show modest improvements in skin roughness and fine-line depth over 12 weeks of twice-daily application.

Primary uses

Topical anti-aging cosmetic formulations

Typical dosing

3–5 % (topical formulation) twice daily (topical)

Cosmetic concentrations.

Regulatory status

Cosmetic ingredient; not a drug. Marketed by Sederma in multiple formulations (original Matrixyl, Matrixyl 3000, Matrixyl Synthe'6).

References

[pubmed] Robinson LR, et al. "Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin." Int J Cosmet Sci, 2005;27:155-160.
[pubmed] Katayama K, et al. "A pentapeptide from type I procollagen promotes extracellular matrix production." J Biol Chem, 1993;268:9941-9944.

Related peptides

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

SNAP-8

An octapeptide cosmetic ingredient extending the Argireline concept — same SNAP-25 competitive mechanism with two additional residues and claims of enhanced activity.

GHK-Cu

A naturally occurring human tripeptide-copper complex with extensive topical cosmetic evidence and strong in-vitro data on collagen synthesis, angiogenesis, and anti-inflammatory signaling.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.