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Evidence: LowPeptide Research Only Cosmetic & Skin

Acetyl Hexapeptide-51 Amide

also known as: Ac-YEKLQV-NH2

Ac-YEKLQV-NH2, a cosmetic hexapeptide sold for ageing skin. PubMed holds no study of it.

Acetyl hexapeptide-51 amide is a synthetic hexapeptide amide, Ac-Tyr-Glu-Lys-Leu-Gln-Val-NH2 (PubChem's record, under its INCI name). It is sold as an anti-ageing ingredient, but a title-and-abstract search of PubMed for its INCI name finds no study of it. It is not a drug.

No dosing data yet Details ↓

Dosing

Recommended Dosing

No dosing data yet

This page has no dosing data yet.

Mechanism of action

Not established: no published study describes its action.

Primary uses

Cosmetic skin-care formulations

Typical dosing

Not established for human use

No published study states an amount of this ingredient used on skin, and a supplier's use level is not a source on this site, so none is given.

Regulatory status

Not a drug: PubChem lists it under its INCI name as a cosmetic ingredient (CID 177866281). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).

Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.

What we checked

Acetyl Hexapeptide-51 Amide is a cosmetic peptide ingredient with little or no published literature; this section records what can be checked.

Identity, computed

Sequence	Ac-Tyr-Glu-Lys-Leu-Gln-Val-NH2 (Ac-YEKLQV-NH2)
Formula	C38H61N9O11
Average mass	819.96 g/mol
Monoisotopic mass	819.4491 Da
Isoelectric point	7.06 (net charge +0.0 at pH 7)

The sequence is the one PubChem's record gives for the INCI ingredient; the values below are computed and agree with PubChem's formula.

Regulatory status, read October 28, 2026

Drugs@FDA: 0 records for “acetyl hexapeptide-51 amide”. EMA medicines list: 0 records for “acetyl hexapeptide-51 amide”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 80 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.

What we looked for and did not find

No published study of any kind, no registry record and no drug approval.

Source	Query	What it was
PubMed	("hexapeptide-51"[tiab] AND acetyl[tiab])	name matched word by word
ClinicalTrials.gov	acetyl hexapeptide-51 amide
Drugs@FDA (openFDA)	acetyl hexapeptide-51 amide
EMA medicines list	acetyl hexapeptide-51 amide

References

[other] PubChem CID 177866281, Acetyl Hexapeptide-51 Amide: formula C38H61N9O11, molecular weight 820.0. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/177866281

Related peptides

Acetyl Hexapeptide-38

Ac-SVVVRT, a cosmetic peptide sold for local volume. Its one human report is a single case in which it was one of three injected agents.

Acetyl Hexapeptide-30

An acetylated six-residue cosmetic peptide sold as Inyline, sequence undisclosed. Its supplier's agrin-MuSK claim is unpublished, and PubMed holds no study of it.

Palmitoyl Pentapeptide-4

The palmitoylated procollagen fragment sold as Matrixyl (pal-KTTKS): in a 12-week split-face trial in 93 women a moisturiser containing it reduced wrinkles more than the same moisturiser alone. A cosmetic ingredient, not a drug.

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Guides & tools

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Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.