Trifluoroacetyl Tripeptide-2
TFA-Val-Tyr-Val, a cosmetic anti-ageing tripeptide. Its only paper on PubMed loads it into a hydrogel; no study tests an effect on skin.
Trifluoroacetyl tripeptide-2 is the tripeptide Val-Tyr-Val with a trifluoroacetyl cap on its N-terminus, sold as an anti-ageing cosmetic ingredient (PubChem lists it under its INCI name). The one paper found on PubMed added it to a supramolecular hydrogel as a model cosmetic active; no study tests what it does in skin. It is not a drug.
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Recommended Dosing
No dosing data yet
This page has no dosing data yet.
Mechanism of action
Not established: no published study describes its action in skin.
Primary uses
- Cosmetic anti-ageing formulations
- Hydrogel-delivery research
Typical dosing
No controlled study of the ingredient on its own states an amount used on skin, and a supplier's use level is not a source on this site, so none is given.
Regulatory status
Not a drug: listed as a cosmetic ingredient under its INCI name (PubChem CID 40785040). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).
Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.
What we checked
Trifluoroacetyl tripeptide-2 is a cosmetic peptide with one formulation paper; this section records what can be checked.
Identity, computed
| Structure | N-(trifluoroacetyl)-Val-Tyr-Val (PubChem CID 40785040) |
| Formula | C21H28F3N3O6 (PubChem) |
| Molecular weight | 475.5 g/mol (PubChem) |
The calculator used elsewhere on this site does not handle a trifluoroacetyl cap, so the formula and weight are PubChem's, not computed here.
Regulatory status, read October 29, 2026
Drugs@FDA: 0 records for “trifluoroacetyl tripeptide-2”. EMA medicines list: 0 records for “trifluoroacetyl tripeptide-2”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 81 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.
What the studies show
A 2023 paper loaded it, with palmitoyl tripeptide-5, into self-healing supramolecular hydrogels designed for skin-pH formulations (Molecules, 2023). It is a formulation study.
What we looked for and did not find
No study of its effect in skin, no human study, no registry record and no drug approval.
| Source | Query | Results, October 29, 2026 | What it was |
|---|---|---|---|
| PubMed | ("tripeptide-2"[tiab] OR "tripeptide 2"[tiab]) AND trifluoroacetyl[tiab] | 1 | the hyphenated INCI name is matched word by word (Q958): a phrase search for a hyphen-numbered name misses papers |
| ClinicalTrials.gov | trifluoroacetyl tripeptide-2 | 0 | |
| Drugs@FDA (openFDA) | trifluoroacetyl tripeptide-2 | 0 | |
| EMA medicines list | trifluoroacetyl tripeptide-2 | 0 |
References
- [other] PubChem CID 40785040, Trifluoroacetyl tripeptide-2: formula C21H28F3N3O6, molecular weight 475.5. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/40785040
- [pubmed] Shariati Pour SR, et al. "Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels." Molecules, 2023;28(6). PMID: 36985499.
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This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.