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Part of the skin and hair peptide hub: every topical and cosmetic peptide we cover, with its evidence grade.

Evidence: LowPeptide Research Only Cosmetic & Skin

Palmitoyl Dipeptide-10

also known as: Pal-Ala-His

Pal-Ala-His, a palmitoylated dipeptide sold for skin-care products. PubMed holds no study of it.

Palmitoyl dipeptide-10 is a synthetic lipopeptide, a palmitoyl group on the dipeptide Ala-His (PubChem's record, under its INCI name). It is sold as a skin-care ingredient, but a title-and-abstract search of PubMed for its INCI name finds no study of it. It is not a drug.

No dosing data yet Details ↓

Mechanism of action

Not established: no published study describes its action.

Primary uses

Typical dosing

Not established for human use

No published study states an amount of this ingredient used on skin, and a supplier's use level is not a source on this site, so none is given.

Regulatory status

Not a drug: PubChem lists it under its INCI name as a cosmetic ingredient (CID 117847167). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).

Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.

What we checked

Palmitoyl Dipeptide-10 is a cosmetic peptide ingredient with little or no published literature; this section records what can be checked.

Identity, computed

Structurepalmitoyl-Ala-His, free acid (PubChem's synonym and IUPAC name, CID 117847167)
FormulaC25H44N4O4 (PubChem)
Molecular weight464.6 g/mol (PubChem)

The calculator used elsewhere on this site does not handle this N-terminal acyl group, so the formula and weight are PubChem's, not computed here.

Regulatory status, read October 28, 2026

Drugs@FDA: 0 records for “palmitoyl dipeptide-10”. EMA medicines list: 0 records for “palmitoyl dipeptide-10”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 80 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.

What we looked for and did not find

No published study of any kind, no registry record and no drug approval.

SourceQueryResults, October 28, 2026What it was
PubMed("dipeptide-10"[tiab] AND palmitoyl[tiab])0name matched word by word in title/abstract (a phrase search misses hyphen-numbered names)
ClinicalTrials.govpalmitoyl dipeptide-100
Drugs@FDA (openFDA)palmitoyl dipeptide-100
EMA medicines listpalmitoyl dipeptide-100

References

  1. [other] PubChem CID 117847167, Palmitoyl Dipeptide-10: formula C25H44N4O4, molecular weight 464.6. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/117847167

Related peptides

Palmitoyl Dipeptide-7

Pal-KT, the smallest palmitoylated peptide in common anti-ageing products. Its studies test it in skin models, in combinations, or in multi-ingredient creams.

Carnosine

β-alanyl-L-histidine, the dipeptide concentrated in muscle and brain that buffers acid and resists glycation; as a supplement, small trials are mixed, and a 299-person trial found no general effect on physical performance.

Palmitoyl Pentapeptide-4

The palmitoylated procollagen fragment sold as Matrixyl (pal-KTTKS): in a 12-week split-face trial in 93 women a moisturiser containing it reduced wrinkles more than the same moisturiser alone. A cosmetic ingredient, not a drug.

Pal-GHK

The palmitoylated form of the GHK tripeptide (distinct from GHK-Cu) — widely used as a cosmetic ingredient in combination with Matrixyl (Matrixyl 3000 is Pal-GHK + Pal-KTTKS) for fine-line reduction.

Guides & tools

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.