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Part of the skin and hair peptide hub: every topical and cosmetic peptide we cover, with its evidence grade.

Evidence: LowPeptide Research Only Cosmetic & Skin

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

also known as: Pal-Lys-Val-Dab-Thr

Pal-Lys-Val-Dab-Thr, one of two lipopeptides in an anti-wrinkle cosmetic blend. PubMed holds no study of it.

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine is a synthetic lipopeptide, a palmitoyl group on Lys-Val-(2,4-diaminobutyroyl)-Thr (PubChem's record, under its INCI name). It is sold as an anti-wrinkle ingredient, usually paired with palmitoyl dipeptide-5 diaminohydroxybutyrate, but PubMed has no study of it. It is not a drug.

No dosing data yet Details ↓

Mechanism of action

Not established: no published study describes its action.

Primary uses

Typical dosing

Not established for human use

No published study states an amount of this ingredient used on skin, and a supplier's use level is not a source on this site, so none is given.

Regulatory status

Not a drug: PubChem lists it under its INCI name as a cosmetic ingredient (CID 72941935). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).

Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.

What we checked

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine is a cosmetic peptide ingredient with little or no published literature; this section records what can be checked.

Identity, computed

Structurepalmitoyl-Lys-Val-(2S)-2,4-diaminobutanoyl-Thr, free acid (PubChem's IUPAC name, CID 72941935)
FormulaC35H68N6O7 (PubChem)
Molecular weight685.0 g/mol (PubChem)

The chain contains 2,4-diaminobutyric acid and a palmitoyl cap, which the calculator used elsewhere on this site does not handle, so the formula and weight are PubChem's, not computed here.

Regulatory status, read October 28, 2026

Drugs@FDA: 0 records for “palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine”. EMA medicines list: 0 records for “palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 80 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.

What we looked for and did not find

No published study of any kind, no registry record and no drug approval.

SourceQueryResults, October 28, 2026What it was
PubMed("dipeptide-5"[tiab] AND palmitoyl[tiab])0name matched word by word; both dipeptide-5 ingredients share this search
ClinicalTrials.govpalmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine0
Drugs@FDA (openFDA)palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine0
EMA medicines listpalmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine0

References

  1. [other] PubChem CID 72941935, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine: formula C35H68N6O7, molecular weight 685.0. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/72941935

Related peptides

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

Pal-Lys-Val-Dab, the shorter of two lipopeptides in an anti-wrinkle cosmetic blend. PubMed holds no study of it.

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Palmitoyl Pentapeptide-4

The palmitoylated procollagen fragment sold as Matrixyl (pal-KTTKS): in a 12-week split-face trial in 93 women a moisturiser containing it reduced wrinkles more than the same moisturiser alone. A cosmetic ingredient, not a drug.

Syn-Ake

A small synthetic peptide sold as a 'snake venom' anti-wrinkle ingredient that mimics waglerin-1. The published work is computer modelling, cell tests and one multi-ingredient serum; no study measures its own effect on wrinkles.

Guides & tools

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.