Part of the skin and hair peptide hub: every topical and cosmetic peptide we cover, with its evidence grade.

Evidence: LowPeptide Research Only Cosmetic & Skin

Acetyl Heptapeptide-4

also known as: Ac-EEMQRRA, Fensebiome

Ac-EEMQRRA, a cosmetic heptapeptide that begins with argireline's six residues. PubMed holds no study of it.

Acetyl heptapeptide-4 is a synthetic heptapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala with a free C-terminal acid (PubChem lists it under its INCI name and the trade name Fensebiome). Its first six residues match argireline's, but the added alanine and the free acid make it a different molecule. A title-and-abstract search of PubMed for its INCI name finds no study of it. It is not a drug.

No dosing data yet Details ↓

Dosing

Recommended Dosing

No dosing data yet

This page has no dosing data yet.

Mechanism of action

Not established: no published study describes its action.

Primary uses

Cosmetic skin-care formulations

Typical dosing

Not established for human use

No published study states an amount of this ingredient used on skin, and a supplier's use level is not a source on this site, so none is given.

Regulatory status

Not a drug: PubChem lists it under its INCI name as a cosmetic ingredient (CID 138756748). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).

Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.

What we checked

Acetyl Heptapeptide-4 is a cosmetic peptide ingredient with little or no published literature; this section records what can be checked.

Identity, computed

Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala (Ac-EEMQRRA)
Formula	C37H64N14O14S
Average mass	961.06 g/mol
Monoisotopic mass	960.4447 Da
Isoelectric point	4.26 (net charge -1.0 at pH 7)

The sequence is the one PubChem's record gives for the INCI ingredient; the values below are computed and agree with PubChem's formula.

Regulatory status, read October 28, 2026

Drugs@FDA: 0 records for “acetyl heptapeptide-4”. EMA medicines list: 0 records for “acetyl heptapeptide-4”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 80 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.

What we looked for and did not find

No published study of any kind, no registry record and no drug approval.

Source	Query	What it was
PubMed	("heptapeptide-4"[tiab] AND acetyl[tiab])	name matched word by word in title/abstract (a phrase search misses hyphen-numbered names)
ClinicalTrials.gov	acetyl heptapeptide-4
Drugs@FDA (openFDA)	acetyl heptapeptide-4
EMA medicines list	acetyl heptapeptide-4

References

[other] PubChem CID 138756748, Acetyl Heptapeptide-4: formula C37H64N14O14S, molecular weight 961.1. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/138756748

Related peptides

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Acetyl Octapeptide-3

Argireline's sequence with two more amino acids, sold as SNAP-8. Its only human data come from microneedle patches that combined it with other actives.

Acetyl Hexapeptide-30

An acetylated six-residue cosmetic peptide sold as Inyline, sequence undisclosed. Its supplier's agrin-MuSK claim is unpublished, and PubMed holds no study of it.

Syn-Ake

A small synthetic peptide sold as a 'snake venom' anti-wrinkle ingredient that mimics waglerin-1. The published work is computer modelling, cell tests and one multi-ingredient serum; no study measures its own effect on wrinkles.

Guides & tools

Explore with tools

Glossary → Peptide Comparison → Beginner's Guide → Peptide FAQ → All Cosmetic peptides →

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.