Acetyl Hexapeptide-49
Ac-FFWFHV, a cosmetic peptide sold for sensitive skin. A 2021 review found it in such products; no study of it is on PubMed.
Acetyl hexapeptide-49 is a synthetic hexapeptide, Ac-Phe-Phe-Trp-Phe-His-Val (PubChem lists it under its INCI name and the trade name Delisens). A 2021 review of facial products for sensitive skin found it among the peptides used and noted that the supporting data are mostly in patents and supplier brochures. No study of it is on PubMed. It is not a drug.
No dosing data yet Details ↓
Recommended Dosing
No dosing data yet
This page has no dosing data yet.
Mechanism of action
Not established: no published study describes its action.
Primary uses
- Cosmetic products for sensitive skin
Typical dosing
No published study states an amount of this ingredient used on skin, and a supplier's use level is not a source on this site, so none is given.
Regulatory status
Not a drug: PubChem lists it under its INCI name as a cosmetic ingredient (CID 162625096). Drugs@FDA and the EMA medicines list hold no record for it (searched October 28, 2026).
Status as of this entry's last review, October 28, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.
What we checked
Acetyl Hexapeptide-49 is a cosmetic peptide ingredient with little or no published literature; this section records what can be checked.
Identity, computed
| Sequence | Ac-Phe-Phe-Trp-Phe-His-Val (Ac-FFWFHV) |
| Formula | C51H57N9O8 |
| Average mass | 924.07 g/mol |
| Monoisotopic mass | 923.433 Da |
| Isoelectric point | 5.05 (net charge -0.76 at pH 7) |
The sequence is the one PubChem's record gives for the INCI ingredient; the values below are computed and agree with PubChem's formula.
Regulatory status, read October 28, 2026
Drugs@FDA: 0 records for “acetyl hexapeptide-49”. EMA medicines list: 0 records for “acetyl hexapeptide-49”. Run for semaglutide, the same queries return 6 and 5 records (and the registry search 80 trials), so a zero here is an absence, not a broken search. Not named on the WADA 2026 and 2027 Prohibited Lists. As a substance with no current approval for human therapeutic use, it falls under section S0 (non-approved substances), which is prohibited at all times; the lists were read on October 28, 2026.
What the studies show
A 2021 review of 88 facial products for sensitive skin listed acetyl hexapeptide-49 among the peptides found and noted that the evidence for them is mostly in patents and supplier brochures (Resende et al., 2021).
What we looked for and did not find
No study of the peptide itself, in people or in the laboratory, no registry record and no drug approval.
| Source | Query | Results, October 28, 2026 | What it was |
|---|---|---|---|
| PubMed | ("hexapeptide-49"[tiab] OR "hexapeptide 49"[tiab]) AND acetyl[tiab] | 1 | the hyphenated INCI name is matched word by word (Q958): a phrase search for a hyphen-numbered name misses papers |
| ClinicalTrials.gov | acetyl hexapeptide-49 | 0 | |
| Drugs@FDA (openFDA) | acetyl hexapeptide-49 | 0 | |
| EMA medicines list | acetyl hexapeptide-49 | 0 |
References
- [other] PubChem CID 162625096, Acetyl Hexapeptide-49: formula C51H57N9O8, molecular weight 924.1. Read October 28, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/162625096
- [review] Resende DISP, et al. "Usage of Synthetic Peptides in Cosmetics for Sensitive Skin." Pharmaceuticals (Basel), 2021;14(8). PMID: 34451799.
Related peptides
Guides & tools
Explore with tools
This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.