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supplement Cosmetic & Skin

Palmitoyl Tetrapeptide-7

also known as: Pal-GQPR, Palmitoyl Tetrapeptide-3, Rigin Palmitoyl

The anti-inflammatory partner in Matrixyl 3000 — a lipopeptide that reduces IL-6 and glycation damage in aging skin.

A lipopeptide (palmitoyl-GQPR) that reduces IL-6 secretion and glycation-induced inflammation in the skin, commonly paired with Palmitoyl Tripeptide-1 as the commercial complex Matrixyl 3000.

Mechanism of action

Reduces IL-6 secretion from keratinocytes and fibroblasts, dampening inflammaging that accelerates collagen degradation. Combined with Palmitoyl Tripeptide-1 (collagen stimulator) for dual-mechanism anti-aging.

Primary uses

  • Anti-aging cosmeceutical (Matrixyl 3000)
  • Reducing skin inflammation
  • Anti-glycation

Typical dosing

2-5 % in formulation 1-2 times daily (topical)

Used in serums and creams.

Regulatory status

Cosmetic ingredient, not FDA-approved as a drug. Commercially available as Matrixyl 3000 (Sederma/Croda).

References

  1. [pubmed] Schagen SK. "Topical peptide treatments with effective anti-aging results." Cosmetics. 2017;4(2):16.

Related peptides

Palmitoyl Tripeptide-38

Sederma's Matrixyl Synthe'6 — a palmitoyl tripeptide (Pal-KMO2K) claimed to stimulate six dermal-matrix components (collagens I / III / IV, fibronectin, hyaluronic acid, laminin-5). Follow-on to Matrixyl and Matrixyl 3000; almost all efficacy data is manufacturer-generated.

Palmitoyl Tripeptide-5

Syn-Coll / Pal-KVK — a palmitoyl tripeptide modeled on the thrombospondin-1 motif that activates latent TGF-β. Mechanistically distinct from Matrixyl-family matrikines: activates a growth-factor signalling pathway rather than directly mimicking collagen fragments. Cosmetic ingredient only.

Palmitoyl Pentapeptide-4

The collagen-boosting cosmetic peptide — a palmitoylated 5-amino-acid fragment that signals fibroblasts to produce more collagen, documented in double-blind studies to reduce wrinkle depth.

Matrixyl

A palmitoylated pentapeptide derived from a collagen-I breakdown fragment (KTTKS) — widely used in cosmetic topicals with clinical data supporting modest reductions in fine-line depth over 12 weeks.

Rigin

A cosmetic tetrapeptide marketed as an anti-inflammatory "Matrixyl companion" — claimed to reduce IL-6 and dampen glycation-driven skin aging; co-formulated with Pal-KTTKS + Pal-GHK in Matrixyl 3000+Rigin products.
Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.