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Part of the skin and hair peptide hub: every topical and cosmetic peptide we cover, with its evidence grade.

Evidence: LowPeptide supplement Cosmetic & Skin

Palmitoyl Tetrapeptide-7

also known as: Pal-GQPR, Palmitoyl Tetrapeptide-3, Rigin Palmitoyl

The anti-inflammatory partner in Matrixyl 3000 — a lipopeptide that reduces IL-6 and glycation damage in aging skin.

A lipopeptide (palmitoyl-GQPR) that reduces IL-6 secretion and glycation-induced inflammation in the skin, commonly paired with Palmitoyl Tripeptide-1 as the commercial complex Matrixyl 3000.

Mechanism of action

Reduces IL-6 secretion from keratinocytes and fibroblasts, dampening inflammaging that accelerates collagen degradation. Combined with Palmitoyl Tripeptide-1 (collagen stimulator) for dual-mechanism anti-aging.

Primary uses

  • Anti-aging cosmeceutical (Matrixyl 3000)
  • Reducing skin inflammation
  • Anti-glycation

Typical dosing

No sourced amount

The concentrations in circulation come from the ingredient's supplier, and a seller's figure is not a source on this site; no study in the sources read sets one.

Regulatory status

Cosmetic ingredient, not FDA-approved as a drug. Commercially available as Matrixyl 3000 (Sederma/Croda).

Status as of this entry's last review, October 4, 2026. Approvals, compounding rules and sport rules change; the regulatory tracker is checked more often.

What the studies show

Palmitoyl tetrapeptide-7 (formerly palmitoyl tetrapeptide-3, sold as Rigin) is the tetrapeptide Gly-Gln-Pro-Arg with a fatty-acid tail. The study below is about that unmodified tetrapeptide, called rigin, which was isolated from human antibody protein; no study has tested the palmitoylated form alone in people.

In Vitro · 1981

The parent tetrapeptide

Gly-Gln-Pro-Arg, a fragment of human IgG, was synthesised and stimulated phagocytosis as strongly as tuftsin, which its folded shape resembles.

PMID 7309346

References

  1. [other] Schagen SK. "Topical peptide treatments with effective anti-aging results." Cosmetics, 2017;4(2):16. doi:10.3390/cosmetics4020016 (MDPI Cosmetics is not indexed in PubMed, so no PMID exists).
  2. [pubmed] Veretennikova NI, et al. "Rigin, another phagocytosis-stimulating tetrapeptide isolated from human IgG. Confirmations of a hypothesis." Int J Pept Protein Res, 1981;17(4):430-5. PMID: 7309346.

Related peptides

Palmitoyl Tripeptide-38

Sederma's Matrixyl Synthe'6 — a palmitoyl tripeptide (Pal-KMO2K) claimed to stimulate six dermal-matrix components (collagens I / III / IV, fibronectin, hyaluronic acid, laminin-5). Follow-on to Matrixyl and Matrixyl 3000; almost all efficacy data is manufacturer-generated.

Palmitoyl Tripeptide-5

Syn-Coll / Pal-KVK — a palmitoyl tripeptide modeled on the thrombospondin-1 motif that activates latent TGF-β. Mechanistically distinct from Matrixyl-family matrikines: activates a growth-factor signalling pathway rather than directly mimicking collagen fragments. Cosmetic ingredient only.

Palmitoyl Pentapeptide-4

The palmitoylated procollagen fragment sold as Matrixyl (pal-KTTKS): in a 12-week split-face trial in 93 women a moisturiser containing it reduced wrinkles more than the same moisturiser alone. A cosmetic ingredient, not a drug.

Guides & tools

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.