Research Only Cosmetic & Skin

Rigin

also known as: Palmitoyl Tetrapeptide-7, Pal-Gly-Gln-Pro-Arg

A cosmetic tetrapeptide marketed as an anti-inflammatory "Matrixyl companion" — claimed to reduce IL-6 and dampen glycation-driven skin aging; co-formulated with Pal-KTTKS + Pal-GHK in Matrixyl 3000+Rigin products.

Palmitoyl tetrapeptide-7, a palmitoylated tetrapeptide developed by Sederma as a cosmetic ingredient claimed to reduce cutaneous IL-6 expression and dampen inflammation associated with glycation-driven skin aging; commonly co-formulated with Pal-KTTKS and Pal-GHK.

Mechanism of action

Claimed by the manufacturer to modulate inflammatory cytokine expression (particularly IL-6) in keratinocytes and fibroblasts in response to glycation and UV damage. Independent mechanistic replication is limited; most evidence comes from Sederma in-house studies.

Primary uses

Topical cosmetic anti-aging formulations (anti-inflammatory, anti-glycation)

Typical dosing

3–5 % (topical formulation) twice daily (topical)

Cosmetic concentrations.

Regulatory status

Cosmetic ingredient; not a drug.

References

[manufacturer] Sederma. "Rigin technical data sheet and cosmetic ingredient profile."

Related peptides

Matrixyl

A palmitoylated pentapeptide derived from a collagen-I breakdown fragment (KTTKS) — widely used in cosmetic topicals with clinical data supporting modest reductions in fine-line depth over 12 weeks.

Pal-GHK

The palmitoylated form of the GHK tripeptide (distinct from GHK-Cu) — widely used as a cosmetic ingredient in combination with Matrixyl (Matrixyl 3000 is Pal-GHK + Pal-KTTKS) for fine-line reduction.

Argireline

A cosmetic-industry hexapeptide marketed as "topical Botox" — reduces muscle contraction signaling at the neuromuscular junction; modest but documented effects on expression-line depth.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.