Research Only Cognitive & Nootropic

Galanin

also known as: GAL, Galanin-1-30

A neuropeptide with uniquely broad functions — modulating seizures, pain, mood, and neurogenesis across three receptor subtypes.

A 29/30-amino-acid neuropeptide widely expressed in the CNS and PNS that inhibits neurotransmitter release via GalR1-3 receptors, with roles in seizure suppression, nociception, mood regulation, and nerve regeneration after injury.

Mechanism of action

Binds GalR1 (Gi-coupled, inhibitory — anticonvulsant/anxiolytic), GalR2 (Gq/Gi — neurotrophic, neurogenesis), GalR3 (Gi — anxiety/depression). Massively upregulated (10-100x) in dorsal root ganglia after nerve injury, promoting nerve regeneration.

Primary uses

Endogenous seizure suppression
Nociception modulation
Nerve regeneration after injury
Research target for epilepsy gene therapy

Typical dosing

N/A N/A N/A (endogenous)

Not used as a drug. Stable analog NAX 5055 has shown anticonvulsant efficacy in rodent models.

Regulatory status

Not approved. GalR2 agonists are in preclinical development for epilepsy, depression, and neuropathic pain.

References

[pubmed] Tatemoto K, et al. "Galanin -- a novel biologically active peptide from porcine intestine." FEBS Lett. 1983;164(1):124-128.
[review] Lang R, et al. "Physiology, signaling, and pharmacology of galanin peptides and receptors." Pharmacol Rev. 2015;67(1):118-175.

Related peptides

Neuropeptide Y

The brain's most abundant neuropeptide — a 36-amino-acid master regulator of appetite, stress resilience, and anxiety that connects metabolic and cognitive peptide networks.

Neurotensin

A gut-brain peptide that modulates dopamine transmission, pain sensitivity, and fat absorption — linking metabolic health to schizophrenia and addiction research.

Noopept

A Russian-developed prolyl-glycine-ester nootropic — often grouped with racetams despite being a dipeptide, with BDNF/NGF upregulation and anxiolytic activity.

Selank

A Russian-developed tuftsin analog approved for anxiety — produces benzodiazepine-like anxiolysis via GABAergic modulation without sedation, dependence, or withdrawal.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.