Research Only Cognitive & Nootropic

NA-Selank Amidate

also known as: N-Acetyl Selank Amidate, Acetylated Selank

An enhanced Selank derivative — N-terminal acetylation and C-terminal amidation improve protease resistance and nasal absorption, extending the anxiolytic and nootropic profile.

A chemically modified version of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) with N-acetyl and C-amide terminal modifications conferring greater enzymatic stability and enhanced CNS penetration via intranasal delivery.

Mechanism of action

Same as Selank: modulates GABA-A receptor allosteric sites, increases BDNF expression, and influences IL-6 and enkephalin metabolism. The N-acetyl modification blocks aminopeptidase degradation; the C-amide blocks carboxypeptidase attack. Net result is longer residence time at target receptors and improved intranasal-to-CNS delivery.

Primary uses

Anxiolytic nootropic (research/community use)
Enhanced Selank analog research
BDNF modulation studies

Typical dosing

200–600 mcg 1–2 times daily (intranasal)

Community-reported dosing. No clinical trials for this specific derivative.

Regulatory status

Not approved by any regulatory body. Available through research peptide vendors. Parent compound Selank is approved in Russia.

References

[pubmed] Derived from Selank literature. No independent publications on the acetylated/amidated form.

Related peptides

Selank

A Russian-developed tuftsin analog approved for anxiety — produces benzodiazepine-like anxiolysis via GABAergic modulation without sedation, dependence, or withdrawal.

Semax

A synthetic ACTH-derived heptapeptide approved in Russia for stroke rehabilitation and optic nerve disorders, with documented BDNF upregulation and broad nootropic activity.

Noopept

A Russian-developed prolyl-glycine-ester nootropic — often grouped with racetams despite being a dipeptide, with BDNF/NGF upregulation and anxiolytic activity.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.