Bronchogen

also known as: Ala-Glu-Asp-Leu, AEDL

A Khavinson tetrapeptide from bronchial tissue — proposed to support respiratory epithelium function in chronic obstructive airway disease; evidence is preliminary and Russian-language.

One of the Khavinson short-chain bioregulators (Ala-Glu-Asp-Leu), derived from bronchial mucosal extract and proposed to support epithelial regeneration and ciliary function in aging lung tissue and in chronic obstructive pulmonary disease models.

Mechanism of action

Proposed to act on bronchial epithelial cells via promoter binding to upregulate expression of genes supporting ciliary function and epithelial repair. Khavinson-group animal studies report reduced inflammation and improved mucociliary clearance in experimental COPD models.

Primary uses

Investigational adjunct in chronic obstructive pulmonary disease (Russian literature)
Research into respiratory aging

Typical dosing

not established not established (oral (capsule) or intranasal)

Russian supplement protocols typically use 10 mg oral capsules once daily for 10–20 days.

Regulatory status

Not FDA-approved. Marketed in Russia as a bioregulator supplement.

References

[pubmed] Khavinson VK, Kuznik BI, Ryzhak GA. "Peptide bioregulators: a new class of geroprotectors. Message 1. Results of experimental studies." Adv Gerontol, 2012;25:696-708.
[review] Khavinson VK, Malinin VV. "Gerontological aspects of genome peptide regulation." Karger AG, Basel, 2005.

Related peptides

Chonluten

A Khavinson tripeptide studied for bronchial epithelium regeneration and anti-inflammatory effects in the respiratory tract — evidence base is Russian-language and preliminary.

Cortagen

A Khavinson-group tetrapeptide isolated from cortex tissue — used in Russian neurology practice for post-stroke cognitive deficit; evidence is almost entirely Russian-language with minimal Western replication.

Epithalon

A synthetic pineal tetrapeptide from the Khavinson group (St. Petersburg) — the only peptide with published data claiming telomerase activation and telomere elongation in human cell models.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.