Chonluten

also known as: Glu-Asp-Gly, EDG tripeptide

A Khavinson tripeptide studied for bronchial epithelium regeneration and anti-inflammatory effects in the respiratory tract — evidence base is Russian-language and preliminary.

A Khavinson short-chain tripeptide (Glu-Asp-Gly) proposed to modulate gene expression in bronchial epithelium and alveolar cells, with reported anti-inflammatory and epithelial-regenerative effects in Russian animal-model and early clinical literature in chronic respiratory disease.

Mechanism of action

Proposed to bind promoter regions in bronchial and alveolar cells, upregulating expression of genes that support mucosal repair and downregulating pro-inflammatory signaling. Animal studies from the Khavinson group report reduced airway inflammation in experimental models.

Primary uses

Investigational support in chronic respiratory disease (Russian literature)
Research into respiratory aging

Typical dosing

not established not established (oral (capsule) or intranasal)

Typical supplement dosing is 10 mg daily in short cyclical courses.

Regulatory status

Not FDA-approved. Marketed in Russia as a bioregulator supplement.

References

[pubmed] Khavinson VK, Kuznik BI, Ryzhak GA. "Peptide bioregulators: a new class of geroprotectors. Message 2. Clinical studies." Adv Gerontol, 2013;26:20-37.

Related peptides

Bronchogen

A Khavinson tetrapeptide from bronchial tissue — proposed to support respiratory epithelium function in chronic obstructive airway disease; evidence is preliminary and Russian-language.

Cortagen

A Khavinson-group tetrapeptide isolated from cortex tissue — used in Russian neurology practice for post-stroke cognitive deficit; evidence is almost entirely Russian-language with minimal Western replication.

Epithalon

A synthetic pineal tetrapeptide from the Khavinson group (St. Petersburg) — the only peptide with published data claiming telomerase activation and telomere elongation in human cell models.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.