Livagen

also known as: Lys-Glu-Asp-Ala, KEDA

A Khavinson tetrapeptide proposed to support hepatic and lymphocyte function; reported to decondense chromatin in aged lymphocytes in in-vitro studies — Russian-language evidence, no Western replication.

A Khavinson-group short tetrapeptide (Lys-Glu-Asp-Ala) proposed to act on lymphoid and hepatic tissues, with in-vitro reports of chromatin decondensation and restoration of gene-expression patterns in aged lymphocytes.

Mechanism of action

Khavinson-group in-vitro studies report that Livagen causes chromatin decondensation in aged lymphocytes and restores transcriptional activity at heterochromatin regions that become silenced with age. The hypothesized in-vivo effect is restoration of immune-cell gene expression in aged animals.

Primary uses

Investigational support for hepatic and immune aging (Russian literature)
Research into chromatin aging

Typical dosing

not established not established (oral (capsule))

Typical supplement protocols use 10 mg daily for 10–20 days.

Regulatory status

Not FDA-approved. Marketed in Russia as a bioregulator supplement.

References

[pubmed] Khavinson VK, et al. "Activating effect of peptides Lys-Glu-Asp-Ala and Ala-Glu-Asp-Gly on chromatin of old lymphocytes." Bull Exp Biol Med, 2011;150:505-507.
[review] Khavinson VK, Malinin VV. "Gerontological aspects of genome peptide regulation." Karger AG, Basel, 2005.

Related peptides

Epithalon

A synthetic pineal tetrapeptide from the Khavinson group (St. Petersburg) — the only peptide with published data claiming telomerase activation and telomere elongation in human cell models.

Ovagen

A Khavinson tripeptide proposed to support hepatocyte function and reproductive-tissue aging; evidence is Russian-language and pre-clinical.

Thymulin

A zinc-dependent thymic peptide — biologically active only when zinc-saturated, making serum thymulin activity a functional readout of zinc status.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.