Ovagen

also known as: Glu-Asp-Leu, EDL tripeptide

A Khavinson tripeptide proposed to support hepatocyte function and reproductive-tissue aging; evidence is Russian-language and pre-clinical.

A Khavinson-group short tripeptide (Glu-Asp-Leu) marketed as a hepatic bioregulator with proposed effects on hepatocyte regeneration and on reproductive-tissue aging in the Russian clinical bioregulator literature.

Mechanism of action

Proposed to bind promoter regions in hepatocytes and reproductive-tissue cells to support tissue-specific gene expression. Animal studies from the Khavinson group report improved hepatocyte function after induced liver injury.

Primary uses

Investigational hepatic support (Russian literature)
Research into reproductive-tissue aging

Typical dosing

not established not established (oral (capsule))

Typical supplement protocols use 10 mg daily for 10–20 days.

Regulatory status

Not FDA-approved. Marketed in Russia as a bioregulator supplement.

References

[review] Khavinson VK, Malinin VV. "Gerontological aspects of genome peptide regulation." Karger AG, Basel, 2005.
[pubmed] Khavinson VK, Kuznik BI, Ryzhak GA. "Peptide bioregulators: a new class of geroprotectors. Message 1. Results of experimental studies." Adv Gerontol, 2012;25:696-708.

Related peptides

Livagen

A Khavinson tetrapeptide proposed to support hepatic and lymphocyte function; reported to decondense chromatin in aged lymphocytes in in-vitro studies — Russian-language evidence, no Western replication.

Epithalon

A synthetic pineal tetrapeptide from the Khavinson group (St. Petersburg) — the only peptide with published data claiming telomerase activation and telomere elongation in human cell models.

Cortagen

A Khavinson-group tetrapeptide isolated from cortex tissue — used in Russian neurology practice for post-stroke cognitive deficit; evidence is almost entirely Russian-language with minimal Western replication.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.