Pinealon

also known as: Glu-Asp-Arg, EDR tripeptide

A Khavinson tripeptide proposed to cross the blood–brain barrier and support neuronal gene expression in aging brain tissue — animal data in hypoxia and oxidative stress models; no Western clinical trials.

A Khavinson-group short tripeptide (Glu-Asp-Arg) proposed to cross the blood–brain barrier and act on neuronal DNA promoter regions to support survival under oxidative stress, with published animal data in cerebral hypoxia and oxidative-damage models but no controlled Western clinical evidence.

Mechanism of action

Proposed to enter neurons and bind promoter regions supporting expression of antioxidant and anti-apoptotic gene programs. Animal studies from the Khavinson group report reduced neuronal damage after induced hypoxia and hydrogen-peroxide oxidative stress.

Primary uses

Investigational neuroprotection (Russian literature)
Research into cognitive aging

Typical dosing

not established not established (oral (capsule))

Typical supplement protocols use 10–20 mg daily for 10–20 days.

Regulatory status

Not FDA-approved. Marketed in Russia as a bioregulator supplement.

References

[pubmed] Khavinson V, et al. "Peptide EDR prevents hypoxia-induced neuronal death in rat cortical cells." Bull Exp Biol Med, 2012;153:115-117.
[pubmed] Kolchina N, et al. "Short peptides prevent hypoxia-induced death of cortical neurons." Exp Gerontol, 2016;83:131-134.

Related peptides

Epithalon

A synthetic pineal tetrapeptide from the Khavinson group (St. Petersburg) — the only peptide with published data claiming telomerase activation and telomere elongation in human cell models.

Cortagen

A Khavinson-group tetrapeptide isolated from cortex tissue — used in Russian neurology practice for post-stroke cognitive deficit; evidence is almost entirely Russian-language with minimal Western replication.

Cerebrolysin

A porcine-derived neurotrophic peptide preparation approved in 40+ countries (not US) for stroke, dementia, and traumatic brain injury — with the largest clinical evidence base of any nootropic peptide preparation.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.