Cartalax

also known as: Ala-Glu-Asp, AED tripeptide

A Khavinson tripeptide from cartilage tissue extract — proposed to support chondrocyte function and joint tissue homeostasis in aging and osteoarthritis models; mostly pre-clinical Russian-language evidence.

A Khavinson short-chain tripeptide (Ala-Glu-Asp) proposed to act as a tissue-specific transcriptional modulator in chondrocytes, supporting cartilage matrix synthesis and joint tissue homeostasis in osteoarthritis and joint-aging models.

Mechanism of action

Proposed to bind chondrocyte DNA promoter regions and upregulate expression of collagen II, aggrecan, and related matrix proteins while downregulating matrix metalloproteinase expression. Western mechanistic validation is limited.

Primary uses

Investigational support in osteoarthritis and joint aging (Russian literature)
Research into connective-tissue aging

Typical dosing

not established not established (oral (capsule))

Typical supplement protocols use 10 mg daily for 10–20 days.

Regulatory status

Not FDA-approved. Marketed in Russia as a bioregulator supplement.

References

[pubmed] Khavinson VK, Kuznik BI, Ryzhak GA. "Peptide bioregulators: a new class of geroprotectors. Message 1. Results of experimental studies." Adv Gerontol, 2012;25:696-708.

Related peptides

Cortagen

A Khavinson-group tetrapeptide isolated from cortex tissue — used in Russian neurology practice for post-stroke cognitive deficit; evidence is almost entirely Russian-language with minimal Western replication.

Epithalon

A synthetic pineal tetrapeptide from the Khavinson group (St. Petersburg) — the only peptide with published data claiming telomerase activation and telomere elongation in human cell models.

TB-500

A synthetic fragment of thymosin β4 studied in animal models for actin-binding-mediated tissue repair, particularly in cardiac and soft-tissue injury.

Disclaimer

This entry is for educational purposes only and does not constitute medical advice. Dosing information reflects published regulatory or research data and is not a recommendation. Many compounds described here are not approved for human use in the United States. Consult a licensed medical professional before considering any peptide therapy.